Phil Garner
Address
Fulmer 466
Pullman, WA 99164-4630
(509) 335-7620
email: ppg@wsu.edu
Garner Group Research Page
Education
- BS Chemistry, 1977
University of Pittsburgh, Pittsburgh, PA - PhD Organic Chemistry, 1981
University of Pittsburgh, Pittsburgh, PA
Research
My group is involved in the design and synthesis of biologically active molecules as well as the development of new enabling chemistries. In this context, our intellectual activities may be viewed as architecture (design and construction) on the molecular scale. Chemical synthesis (the discipline associated with building molecular structures) is the common element that underlies all of our research endeavors. Because synthesis is an integral part of the drug development process, this area of research is at the cutting edge of molecular based therapeutics. Students in the Garner group learn how to apply the tools of organic chemistry to important problems that span the traditional disciplines.
Publications
Isleyen, A; Gonsky, C.; Ronald, R. C.; Garner, P. “Efficacious Preparation of Oppolzer’s Glycylsultam via the Delépine Reaction” Synthesis 2009 – in press.
Kahsai, A. W.; Cui, J.; Kaniskan, H. Ü.; Garner, P. P.; Fenteany, G. “Analogs of Tetrahydroisoquinoline Natural Products that Inhibit Cell Migration and Target Galectin-3 Outside of Its Carbohydrate- Binding Site” J. Biol. Chem. 2008, 283, 24534.
Kaniskan H; Garner, P An Efficient Synthetic Approach to Cyanocycline A and Bioxalomycin b2 via [C+NC+CC] Coupling; J. Am. Chem. Soc. 2007, 129, 15460.
Garner, P.; Hu, J.; Parker, C. J.; Youngs, W. J.; Medvetz, D. "The CuI Catalyzed Exo-Selective Asymmetric Multicomponent [C+NC+CC] Coulping Reaction” Tetrahedron Lett, 2007,48 3867.
Dogan, O.; Koyuncu, H.; Garner, P.; Bulut, A.; Youngs, W. J.; Panzner, M. “New Zinc(II)-Based Catalyst for Asymmetric Azomethine Ylide Cycloaddition Reactions” Org. Lett. 2006, 8, 4687.
Garner, P.; Kaniskan, H. Ü.; Hu, J.; Youngs, W. J.; Panzner, M. “Asymmetric Multicomponent [C+NC+CC] Synthesis of Highly Functionalized Pyrrolidines Catalyzed by Silver(I)” Org. Lett. 2006, 8, 3647.
Garner, P.; Sesenoglu, Ö.; Kaniskan, H. Ü. “S-(2-Pyrimidinyl)- and S-(2-(4,6-dimethylpyrimidinyl))-1,1,3,3- tetramethylthiouronium hexafluorophosphates: novel reagents for in situ peptide coupling” Tetrahedron Lett. 2006, 47, 483.
Garner, P.; Kaniskan, H. Ü. “Synthesis of Highly Functionalized Pyrrolidines via a Mild One-Pot, Three-Component 1,3-Dipolar Cycloaddition Process” J. Org. Chem. 2005, 70, 10868.