Address

Fulmer 478
Pullman, WA 99164-4630

(509) 335-6073
email: mxian@wsu.edu

Education

• PhD Chemistry, 2003
  Wayne State University, Detroit, MI
• BS Chemistry, 1995
  Nankai University, China

Research

Professor Ming Xian received his B.S. in chemistry from Nankai University, China. He then joined Professor Jin-Pei Cheng's group at Nankai for his early graduate study. In 1999, he moved to the Wayne State University to continue his research under Professor Peng George Wang. After received his Ph.D. in organic chemistry in 2003, he did postdoctoral research with Professor Amos B. Smith, III as a DOD postdoctoral fellow at the University of Pennsylvania. In August 2006, he joined the faculty at the Washington State University in the Department of Chemistry.

The core of Dr. Xian's research interests comprises the desire to combine organic synthesis with bioorganic chemistry to examine, understand, and solve problems of biological and medicinal significance. We are interested in the areas of (1) synthetic methodology development and natural product synthesis; (2) protein molecular recognition and interaction; and (3) the development of new therapeutic agents.

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Publications

• Smith, A. B., III; Xian, M. "Anion relay chemistry: an effective tactic for diversity oriented synthesis" J. Am. Chem. Soc. 2006, 128, 66. Smith, A. B., III; Xian, M. "Design, synthesis and biological evaluation of simplified analogues of discodermolide, additional insights on the importance of the diene, the C(7) hydroxyl, and the lactone" Org. Lett. 2005, 7, 5229.
• Smith, A. B., III; Xian, M.; Liu, F. "Design, total synthesis and evaluation of C13,C14 cyclopropane analogues of discodermolide" Org. Lett. 2005, 7, 4613.
• Smith, A. B., III; Freeze, B. S.; Xian, M.; Hirose, T. "Total synthesis of (+)-Discodermolide: A highly convergent fourth-generation approach" Org. Lett. 2005, 7. 1825-1828.
• Shaw, S. J.; Sundermann, K. F.; Burlingame, M. A.; Myles, D. C.; Freeze, B. S.; Xian, M.; Brouard, I.; Smith, A. B., III. "Toward understanding how the lactone moiety of discodermolide affects activity" J. Am. Chem. Soc. 2005, 127, 6532.
• Xian, M.; Fatima, Z.; Zhang, W.; Fang, J.; Pei, D.; Loo, J.; Stevenson, T.; Wang, P. G. "Identification of alpha-Gal epitope mimetics through rapid generation and screening of C-linked glycopeptide library" J. Comb. Chem. 2004, 6, 126.
• Wang, P. G.; Xian, M.; Tang, X. -P.; Wu, X. -J; Wen, Z.; Cai, T. -W. "Nitric oxide donors: chemical activities and biological applications" Chem. Rev. 2002, 102, 1091.